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In one of the largest real-world studies to date examining obesity treatment use and long-term weight changes after GLP-1 discontinuation, researchers at Cleveland Clinic found that many patients successfully stabilized their weight after one year through alternative treatments and therapeutic lifestyle interventions

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The SURMOUNT-4 trial showed that people who continued tirzepatide after their initial plateau lost an additional 5.5 percent of body weight, while those switched to placebo regained 14 percent

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