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Nutrition 2014
Others take several weeks
Patients with certain genetic profiles may plateau more quickly on standard semaglutide and respond better to tirzepatide or higher doses
This sequential approach serves two purposes: first, to eliminate immortal time bias by properly aligning treatment initiation with follow-up start (T0) and, second, to maximize statistical power by allowing individuals to contribute data across multiple trials
10.1152/japplphysiol.00233.2016 51 CirulliF.BerryA.ChiarottiF.AllevaE
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