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It's which mechanism addresses the specific metabolic question your research is designed to answer
Its about consistency
Similar results were observed in female Bbs5 / mice (Supplemental Figure 3, I and J) as well as heterozygous Bbs5 +/ mice (Supplemental Figure 3, N and R)
When administered with metformin, the C max and AUC of furosemide were 31% and 12% smaller, respectively, than when administered alone, and the terminal half-life was decreased by 32%, without any significant change in furosemide renal clearance
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