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However, when oxidative stress becomes prolonged and cellular systems are no more able to counteract the oxidative-mediated insults, the amount of free GSH decreases leading to irreversible cell degeneration and death
Targeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer's disease immunotherapeutics
Retrieved August 2, 2014
This suggests that M pro might be particularly efficient at disrupting GSH synthesis, as compared to action at some of the other target sites predicted here, thereby contributing to the clinical findings in COVID-19 (7)
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