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[1] Diarrhoea specifically was among the most frequently cited individual symptoms, though the majority of episodes were described as mild to moderate in severity

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Avoid crushing or splitting the tablet, taking it with coffee or juice, eating too soon after the dose, or doubling up after a missed dose

To minimise these effects: Start with the lowest dose (3mg) and increase gradually as prescribed Eat smaller, more frequent meals Avoid high-fat or spicy foods initially Stay well hydrated Take the medication consistently each morning Most gastrointestinal symptoms improve over time as your body adjusts

Our study illustrates the importance of studying ciliopathies, not only as rare genetic disorders but also as critical contributors to metabolic dysregulation in more prevalent forms of obesity