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But MT2

JCI Insight 7 , (2022)

In a large phase 3 obesity trial (ACHIEVE-1), orforglipron at daily doses of 3, 12 and 36 mg caused approximately: Diarrhoea: 1926% of participants (vs 9% on placebo) Nausea: 1318% (vs 2% on placebo) Constipation: 817% (vs 4% on placebo) Vomiting: 514% (vs 1% on placebo) Across multiple studies, 617% of people stopped treatment because of side effects, mostly gut-related symptoms

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Long-term use may be beneficial with proper guidance

Choose appropriate beverages : Water is ideal, but sugar-free squash, herbal teas, and clear broths also contribute to hydration