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First identified in 1973 by researcher Loren Pickart, GHK-Cu emerged from observations that blood plasma from younger individuals could cause older liver tissue to synthesize proteins in patterns characteristic of younger tissue

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suggested that ARA-290 peptide may attenuate age-associated decline in cardiac function in laboratory models, while also potentially reducing systemic inflammation and preserving late-life body weight in aged rat laboratory models

The exact cause is unknown, but factors such as genetics, trauma, hormonal changes, and certain medical conditions may contribute to their development

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