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Venous thromboembolism is closely linked to metabolic disease, with obesity and diabetes promoting a prothrombotic state characterized by endothelial dysfunction, chronic low-grade inflammation, platelet activation, and impaired fibrinolysis ( Being a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, tirzepatide produces substantial reductions in body weight ( Although incretin-based therapies have been extensively evaluated for their effects on atherosclerotic cardiovascular disease, their relationship with venous thromboembolism has been less clearly defined

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The lowest dose for Semaglutide, also known as Wegovy or Ozempic, is 0.25 mg