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Sleep problems in Rett syndrome often include: insomnia: Difficulty falling asleep or staying asleep at night, which is one of the most common complaints for caregivers excessive daytime sleepiness: Feeling a constant need to nap or struggling to stay awake during daylight hours sleep-disordered breathing: Experiencing abnormal breathing patterns that can disrupt the restorative stages of sleep nighttime vocalizations: Laughing, screaming, or talking while asleep, often occurring without the person waking up bruxism: Clenching or grinding the teeth during the night seizures: Experiencing abnormal electrical brain activity while sleeping, which can be difficult to detect The bodys natural circadian rhythms are often disrupted in those with Rett syndrome

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Proper injection technique and rotating injection sites can help prevent injection site issues, including allergic reactions

The concentration of the isotonic agent makes the formulation isotonic