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Evidence from in vitro, animal, and small human studies indicates low toxicity

In one animal model, when compared to platelet-derived growth factor, after eight days it was roughly equivalent (2)

Fluid retention, joint discomfort, headache Mild edema, joint stiffness, and headaches are commonly reported in the IGF-1 pathway literature, including IGF-1 LR3 community reports

High Dose (10 mcg/kg): Typically reserved for acute/severe injuries or advanced orthopedic conditions

Official prescribing information Centers for Disease Control and Prevention

The most critical contraindication is use in neonates and infants