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Sigalos and Pastuszak 2018 identified decreased insulin sensitivity and elevated fasting glucose as a consistent adverse signal across the entire GH secretagogue class, GHRH analogs included, even though the mechanism (preserved pulsatility) is theoretically gentler than fixed-dose GH
This drop-off may be attributed to a subset of patientsoften impulse buyersseeking rapid weight loss rather than committing to long-term therapeutic regimens
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Epub 2014 Mar 5
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