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Orthopedic surgeons need to be cognizant of patients on GLP-1 agonists and council them that they may experience more postoperative nausea and vomiting than patients not taking the medication, Sara E

Furthermore, in a 12-week RCT in which patients were either assigned to liraglutide (1.8 mg/day), sitagliptin (100 mg/day) or placebo, no difference in glycemic control or bodyweight reductions were found, and both treatments failed to reduce liver hepatic fat content compared to placebo (69)

While it effectively bypasses digestion, it introduces higher costs and safety risks compared to oral or topical alternatives