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Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma

For the vast majority of patients without concerning thyroid history, the established benefits significantly outweigh the unproven thyroid concerns

The GCGR components direct effects on hepatic glucose production and lipid metabolism pathways make retatrutide useful for studying liver metabolism at the cellular level

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A nuclear glutathione cycle within the cell cycle