surpass trial tirzepatide Reduction of prevalence of patients meeting the criteria for metabolic syndrome with tirzepatide: a post hoc analysis from the Clinical Program | Cardiovascular Diabetology Post Hoc Analysis of SURPASS-1

2023 Jul 22;26(9):107455

What they tell you is that dosing instructions matter enormously, and that you should follow them exactly as written - not adjust doses yourself, not guess at unit conversions, not copy another patient's protocol

( Conclusion In conclusion, the emerging observation that some complications of diabetes are associated with an hyperactivation of RAAS has provided the pathophysiological basis to study the effects of GLP1-RA and SGLT2-i on RAAS to better explain the cardio-reno-protective effect demonstrated by the clinical trials, beyond their role on glucose control

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We further notice that GLP-1 RA users had a slower eGFR decline, implying a possible effect on kidney function 20,29

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