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MOTS-c is not simply released from the mitochondria and degraded locally

Int J Mol Sci 16(11):2777027780

In IBS-C patients, acute mental and acoustic stress slow intestinal motility and increase the colonic spike-burst activity with higher levels of the vital stress hormone corticotropin-releasing factor (CRF)

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Its reported interactions with circadian-associated pathways, including potential links to melatonin regulation, position DSIP as a model compound for investigating synchronization of biological rhythms and neuroendocrine coordination of sleep processes [3]