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in their preclinical study among murine TT1 thyrotrope cells found that a retinoid X receptor antagonist named LG101208 makes a 71%81% increase in the levels of TSH mRNA in vitro at 24 and 48 h and a 47% to 53% increase in the levels of D2 and glycoprotein -subunit mRNA, and the RXR agonist LG100268 decreases the levels of the glycoprotein -subunit, TSH, and D2 mRNA (79)

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