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Leveraging AlphaFold, the structure of Fks1, the -1,3-glucan synthase targeted by echinocandins, was resolved, revealing resistance-associated mutations, catalytic mechanisms, and the GTP-dependent conformational activation by Rho1 (Hu et al., 2023
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The greatest eryptotic and oxidative changes were caused by TBBPA, while the lowest were associated with its substitute, TBBPS, which highlights the validity of replacing TBBPA with TBBPS [421]
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