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While both drugs work to lower blood sugar, they do so in different ways, which can sometimes lead to an additive effect

Injection site reactions such as redness, itching, or swelling can occur but are typically mild and transient

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Beyond weight loss, TRIUMPH-4 demonstrated significant improvements in osteoarthritis symptoms

Collectively, these data support a self-perpetuating chronometabolic cycle in which circadian disruption both drives and is amplified by MASLD, positioning circadian integrity as a mechanistically central and potentially modifiable axis in disease progression

In some instances, skin symptom improvements occurred even in the absence of significant weight loss or improved glycemic control