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10.1007/s00125-003-1103-y
Herrera F, Martin V, Garca-Santos G, Rodriguez-Blanco J, Antoln I, Rodriguez C
There were 41 genes uniquely overlapping at least 1 MS lesion type and LPC MOLs at demyelination, including genes with roles in neuroprotection ( GDNF ) and lipid metabolism and cholesterol trafficking ( APOE ), glutamatergic and axon-glial ephrin signaling genes ( GRM8, EPHA4 ), interferon signaling and MHC-I regulation ( IRF1, NLRC5 ) and ECM and cell adhesion molecules ( TNR , CNTN3 , ITGA8 )
Combining them without guidance can be unsafe
Patients should discuss their individual circumstances with their GP or specialist to determine eligibility and appropriateness of treatment
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