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The SURMOUNT-1 trial demonstrated 20.9% mean body weight reduction at 72 weeks on tirzepatide 15mg versus 14.9% on semaglutide 2.4mg in the STEP-1 trial, suggesting the dual mechanism produces greater weight loss in head-to-head comparisons

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The medication should be injected subcutaneously into the abdomen, thigh, or upper arm, with rotation of injection sites to prevent lipodystrophy or persistent local reactions