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The ferroptosis pathway is enriched at both 4 and 8 weeks after chronic compression SCI, and MDA content peaked at 4 weeks after chronic compression, decreased at 8 weeks, and was negatively correlated with behavioral scores

No conclusions can be drawn about long-term benefits or risks

Note that combining GLP-1/GIP receptor agonists with DPP-4 inhibitors is not recommended due to overlapping mechanisms

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In this context, GLP-1mediated improvements in brain insulin sensitivity address a foundational energetic deficit rather than a downstream consequence of neurodegeneration [15]

Moreover, given that there are now millions of patient-years of clinical experience with DPP-4 inhibitors since they were given regulatory approval in 2006, their benign, placebo-like side effect profile (39) also suggests that the number of physiologically relevant substrates is likely to be limited