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Managing Digestive Symptoms While Taking GLP-1 Effective management of digestive symptoms can significantly improve tolerability and treatment adherence for patients taking GLP-1 receptor agonists

He also noted that cost and access remain obstacles to using tirzepatide and that the addition of the drug as a treatment could exacerbate racial and other disparities in addressing sleep apnea

For example, more cautious dose titration is recommended in older people owing to increased risk of hypoglycaemia and limited evidence and experience initiating GLP-1 and GIP analogues in people aged over 75 years

[4] [5] Some patients report temporary digestive changes following injections, though the exact mechanism for this is not well established

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Tirzepatide patents run into the early-to-mid 2030s, and peptide drugs follow the biosimilar pathway rather than ordinary generic approval