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The strongest human clinical evidence is for topical use, including the Leyden 2002 photoaging trial and a 2023 NEEL gel topical study reporting an average 28% increase in skin collagen density at 3 months
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While some people with naturally dark skin seek skin bleaching products and procedures due to societal biases against darker skin, there are dozens of reasons for people of all skin tones to consider skin lightening
Furthermore, the contribution of melatonin in relation to modulating the symptoms of PCOS through its involvement with the regulation of appetite and metabolic processes highlights the importance of this part of treatment [188]
Some individuals may also experience redness or itching in the treated area
Cell Reports, 28, 2608-2619.e6
