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Estrogen decline affects insulin sensitivity and fat storage, particularly around the abdomen

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In men, testosterone is produced primarily in the testes, while women produce smaller amounts in the ovaries and adrenal glands

Wegovy is specifically FDA approved for chronic weight management in adults with obesity or who are overweight and have at least one weight-related condition, like high blood pressure or type 2 diabetes

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Its important that people are given advice on improving their diet and exercise, rather than relying solely on the drugs, as this may help them maintain good habits when they stop taking them. There are significant concerns about the long-term consequences of GLP-1R drugs on body composition, with studies indicating that 40 to 60% of the weight lost during treatment is muscle