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A recent perspective article highlighted that semaglutide demonstrated cardiovascular protective effects in individuals with obesity even before significant weight loss, suggesting that GLP-1 RAs may exert cardioprotection through weight-independent mechanisms 33

Weight loss shouldnt feel like a constant uphill battle

Animal models and the Phase 2 human trial both showed meaningful reductions in liver fat, a finding relevant for patients with metabolic-associated steatotic liver disease (MASLD)

It's not clear if the participants followed diet and exercise recommendations

GLP-1s have been shown to reduce inflammatory markers, such as C-reactive protein (CRP), and decrease the production of pro-inflammatory cytokines

Milk thistle is comprised of three active compounds, collectively known as silymarinwhich is well known for its antioxidant propertieswhat researchers believe supports glutathione by preventing cell damage