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Multiple mechanisms may interrelate NNMTi treatment with the microbiome

Maintenance phase: Once the loading phase is complete, patients transition to maintenance therapy with 1 mg hydroxocobalamin intramuscularly every two to three months for life

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The relationship between B12 and bowel changes is typically indirect, relating more to the supplement formulation, excipients (inactive ingredients), or underlying health conditions rather than the vitamin itself

Animal and laboratory studies have produced promising findings related to tissue repair, tendon healing, ligament recovery and gastrointestinal protection