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If too many free radicals build up, they create oxidative stress, which harms cells and speeds up aging

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CNN reported many of the problems some users of these diabetes drugs have experienced, and further reported that doctors are coming forward with reports of gastroparesis by patients who took these medications

Preclinical studies in rodents have identified a potential association between GLP-1 receptor agonists and thyroid C-cell tumours, though there is no confirmed causal link established in humans to date

Weight regain is well documented: the STEP 4 trial found that people who stopped after 20 weeks regained an average of 6.8% of their body weight over the following months

These are not substitutes for titration adjustment, but they increase the chance that a given dose becomes tolerable