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64 Moreover, another study revealed that 3,3-dimethyl-1-Butanol (DMB) reduced the plasma TMAO levels and attenuated the pressure overload-induced cardiac hypertrophy, cardiac fibrosis, and ventricular arrhythmia by inhibiting the p65 NF-B and TGF-1/Smad3 signaling pathway, which may further confirm the role of TMAO in cardiac remodeling

Koizumi A, Nozaki J, Ohura T, Kayo T, Wada Y, Nezu J, Ohashi R, Tamai I, Shoji Y, Takada G, Kibira S, Matsuishi T, Tsuji A: Genetic epidemiology of the carnitine transporter OCTN2 gene in a Japanese population and phenotypic characterization in Japanese pedigrees with primary systemic carnitine deficiency