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Remarkably, regions hypomethylated in Paf15 KRKR ESCs were associated with a significantly earlier replication timing than regions of unchanged DNA methylation, which on average tended to replicate later in S phase (Fig

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208 In metabolic adaptability, the m 6 A RNA methyltransferase METTL16 participates in glutamine biosynthesis by regulating GLUL expression, 209 whereas interferon-related developmental regulator 1 (IFRD1) can modulate cancer cell survival under glutamine deprivation by suppressing histone H1.0 nucleophagy