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Given two alignment columns A and B , each with discrete distributions of amino acids, their MI can be calculated as where x i is one of the 21 symbols at position A , and y j is one of the 21 symbols at position B

19 , e12613 (2020)

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10.1111/j.1365-3059.1995.tb02718.x 98 WangC.WangY.WangY.WangZ.ZhangL.LiangY.et al

For instance, people with diabetes who have high blood sugar are more likely to experience yeast infections