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Similar mechanism to pregabalin with a longer track record
The same FDA document mandates post-marketing trials to demonstrate that the novel agent does not increase cardiovascular risk by more than 30% compared to placebo (henceforth these trials were named cardiovascular outcome trial), if premarketing studies did not already demonstrate this
There was no evidence that patients receiving semaglutide benefited clinically from the treatment
In addition, achievement of a renal composite end point of decline in eGFR to 40% from baseline, death due to kidney disease or progression to end-stage kidney disease, and new-onset macroalbuminuria was 42% lower in study participants receiving tirzepatide compared with insulin glargine ( p = 0.0008)
Semaglutide dosing typically maxes out at 2.4 mg for weight loss or 1.0 mg for diabetes treatment
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