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One possibility is that GSH reduction is particularly pronounced in the thalamus due to its central role in nociceptive processing and pain transmission, as discussed below
The exciting fact is that the depleted glutathione levels that occur with a cytokine storm can severe cases
Ultimately, the understanding of systemic and brain PK of 7,8-DHF among neonatal mice could be applied to larger animal models of neonatal HIE especially the ones that show the kidney and liver injury phenotype that is not present in Vannuccis neonatal rodent model of HI
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