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International Consensus for Diagnosing Lipedema: Uncontrolled localized deposition of fat in the lower extremities Symmetric increase in adipose tissue (two-body syndrome) Onset at puberty, pregnancy, and menopause Women (usually progressive with age) Easy Bruising Tired or heavy legs Mild or severe pain or pressure to touch Hands and feet are usually spared Cuffing or bulging at the joints Stemmers sign is negative Nodules of fat are palpable Limited mobility and decreased social activity* *Adapted from Sandhofer M, et al
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Chronic hyperglycemia can induce circulating accumulation of lipid peroxidation products and impaired iron metabolic pathways, which results in the presence of a variety of free iron in plasma
Changes in Intestinal Microbiota Composition and Metabolism Coincide With Increased Intestinal Permeability in Young Adults Under Prolonged Physiological Stress
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Pitkanen S, Robinson BH
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