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Tolerance development While there is potential to develop tolerance for gastrointestinal side effects over time, this demands consistent adherence and careful dose titration
2 Digital care and dosing for GLP-1 therapy One of the most promising innovations in obesity management is the integration of digital coaching with flexible medication dosing
That puts the Danish drugmaker into a better position to compete with U.S
However, it is not suitable for everyone
In addition, L-leucine prevented muscle degradation in clinical studies [52]
Furthermore, GLP-1 has been shown to stimulate calcitonin secretion from the thyroid gland, which may further contribute to protective effects on bone, 25 but whether this action is relevant in humans still needs to be clarified
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