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Weight Loss with Semaglutide 2.4 mg Once Weekly in Adults with Overweight or Obesity. The New England Journal of Medicine, 384(11), 989-1002

Semaglutide Semaglutide (Wegovy, Ozempic) works on the GLP-1 pathway alone

The American Journal of Clinical Nutrition , 89 (3), 815821

Think of it this way: GLP-1 therapy opens the door to significant fat reduction, but without attention to muscle preservation, some of what walks out that door is tissue the body cannot easily afford to lose