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Originally developed as pharmacological agents for the management of Type 2 diabetes mellitus, these molecules which include semaglutide, liraglutide, and tirzepatide have undergone a remarkable scientific reappraisal over the past several years

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The two most studied incretins, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) stimulate insulin release through specific G-protein-coupled receptors predominantly found on islet cells

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