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Consistent with these findings, physiological measurements demonstrated that melatonin continued to improve airway function in the presence of Luzindole ( Figures 2O, P ), suggesting that receptor-independent mechanisms may contribute to melatonins protective effects in allergic airways disease

Precursor recycling (e.g., NR, NMN) also wanes due to reduced enzyme efficiency in salvage pathways

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The vasoprotective effect of SEM also corresponds to a previous study where SEM decreased vascular leakage in a mouse model of diabetic retinopathy [14]

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