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This steady-state level is what creates the appetite suppression and metabolic benefits that support weight loss
The percentage of participants achieving the composite endpoint was assessed between each of the tirzepatide doses versus comparators using logistic regression at the primary endpoint at week 40 (SURPASS-1, -2, and -5) or week 52 (SURPASS-3 and -4) on the imputed data
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So, it can reduce macrophage infiltration of adipose tissue, inhibit inflammatory pathways in adipocytes and ameliorate insulin sensitivity (98)
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