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An initial analysis of the FDA adverse event reporting system (FAERS) data demonstrated no consistent trends in DKA with SGLT2i use over time [39], however an alternative cohort study of 50,220 individuals with type 2 diabetes showed the highest risk of DKA shortly after SGLT2i initiation, which subsequently reduced with time [40]
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In late 2025, the FDA approved an oral semaglutide formulation (Wegovy oral) for weight management at 25mg and 50mg doses, with clinical trials showing 13-14% body weight reduction
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Peptides and metabolic health for conception is the impact that small proteins can have on metabolism-related issues associated with fertility
38,39,40 The phenotype observed after GLP-1R knockout (KO) includes various physiological and metabolic changes
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