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Bulletin of Experimental Biology and Medicine (2016) 7
"Notice of interim decisions to amend (or not amend) the current Poisons Standard
A., and Greenhaff, P
JIB-04, a pan-inhibitor of histone demethylases, targets histone-lysine-demethylase-dependent AKT pathway, leading to cell cycle arrest and inhibition of cancer stem-like cell properties in hepatocellular carcinoma cells
Controlled research on injured tendon has shown that BPC-157 accelerates the outgrowth, survival, and migration of tendon fibroblasts, the cells that repair damaged (including transected Achilles) tendon, through activation of the FAK-paxillin pathway
Tests in bacteria, cells, and mice all came back negative, suggesting the compound does not pose carcinogenic risk through DNA damage mechanisms
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