glp 1 drugs and menopause Postmenopausal women on the GLP-1 medication tirzepatide (Zepbound) for obesity lost more weight if they were also using hormone therapy, a retrospective cohort study indicated. https://www.medpagetoday.com/endocrinology/menopause/119594 GLP-1 medications peri-menopause - Star

120 Upon activation, Nrf2 is shuttled into the nucleus, where it binds to the antioxidant response element and enhances the expression of antioxidant genes

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The question of whether GLP-1 therapy qualifies as direct immunomodulation or whether the benefits are primarily mediated through weight loss and reduced adipose inflammation is still under active investigation

Among them, oxidative damage to the autonomic nervous system due to iron accumulation associated with diabetes may be due to changes in the NRF2-GPX4 pathway in ferroptosis (113, 114), the transcription factor that regulates SLC7A11 (51) can effectively prevent oxidative damage in various pathological conditions upon NRF2 activation (115, 116)

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