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However, the rate of weight reduction might slow over time [52, 64, 65]

These include: Tier 2 services : Community-based lifestyle interventions Tier 3 services : Specialist multidisciplinary teams for complex obesity Tier 4 services : Bariatric surgery assessment and procedures Referral criteria for these services are outlined in NICE guideline CG189 for obesity management

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But the mechanistic rationale is strong, the safety profile appears favorable, and the early observational data aligns with what the biochemistry predicts

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