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Risk factors for severe cranial ischaemic events in an Italian population-based cohort of patients with giant cell arteritis

The 2024 structural paper by the Wang group provides a side-by-side comparison with semaglutide and tirzepatide bound to their respective receptors

An oxidation pathway, in which jasmonoyl-isoleucine is oxidized by cytochrome P450 enzymes, mainly CYP94 isoforms, to a 12-hydroxy metabolite and then further via a 12aldehydo intermediate to dicarboxy-jasmonoyl-isoleucine, together with deconjugation by amidohydrolases, is now recognized as a major route for catabolism and deactivation of the hormone, although the hydroxy intermediate can itself cause weak and sustainable expression of certain JA-responsive genes until further oxidation occurs

Food & Drug Administration: Donnelly, B

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Ozempic, Wegovy, and other Semaglutide medications used to aid weight loss have seen a recent increase in popularity