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Systematic site rotationchanging locations with each weekly injection across multiple body areaseffectively prevents lipohypertrophy and maintains steady therapeutic levels of semaglutide

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Addiction, constipation, cognitive impairment, and risk for over-dose and respiratory depression create serious concerns

as a result, subcutaneous injections and intranasal delivery are the predominant methods used in research, though both routes present practical challenges for routine clinical use

Clinical trials demonstrated average weight reductions of 15-21% of body weight over 72 weeks in people with obesity (SURMOUNT-1), while more modest weight loss was observed in type 2 diabetes patients (SURPASS trials)

Comprehensive improvement in glycaemia, dyslipidaemia, hepatic steatosis, and cardiovascular markers