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a , Comparison of compound 2 (grey) docked to the GLP-1R crystal structure, after 500 ns molecular dynamics simulation (compound 2 in cyan), and molecular dynamics simulation of PF-06372222-bound GLP-1R (PF-06372222 in pink)

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GLP-1R activation and multifunctional effects GLP-1 has its main effects through the activation of GLP-1R which belongs to the family of G-protein coupled receptors

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GLP1RAs significantly decreased E-wave velocity, E/A ratio, E/e _ ratio, and EDT but did not affect LVEF