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According to the National Institute on Alcohol Abuse and Alcoholism (NIAAA), biological females average approximately 49% total body water as a proportion of body weight, while biological males average approximately 58%

Pharmaceutics 14, 1073

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Deficiencies can occur with medical conditions such as atrophic gastritis (which causes thinning of the stomach lining), pernicious anaemia, Crohns disease, celiac disease, lupus, or other immune system disorders and certain medications

You're going to see these things springing up at the state level