Large, long-term outcome studies show that GLP-1 therapies improve outcomes and reduce the incidence of diseases closely linked to inflammation, including osteoarthritis, cardiovascular disease, fatty liver disease, chronic kidney disease, Alzheimers, and autoimmune conditions
A study of sacral nerve stimulation enrolled 45 participants with at least one year of severe slow or normal-transit constipation and who had not responded to other treatments
The fact that a good number of patients had to stop due to excessive weight loss is eye-opening as well
However, there are several tests that can help to confirm a diagnosis, including: Blood tests to measure levels of glutathione and other markers of liver function Genetic testing to look for mutations in the GSS gene Imaging tests, such as an ultrasound or MRI, to look for liver abnormalities If you suspect that you or a loved one may have glutathione synthetase deficiency, it is important to speak with a genetic counselor or other medical professional who can help guide you through the diagnostic process
Managing weight during a GLP-1 pause This is the elephant in the room
Clinical trials (using the Wegovy formulation) have shown that when combined with lifestyle changes, non-diabetic participants lost about 12-13 percentage points more body weight compared to those taking a placebo over 68 weeks