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Existing data come from clinical trials

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Pericyte-specific Kir6.1 knockout mice were generated by crossing tamoxifen-inducible NG2-Cre ERT2 knock-in mice 68 (kindly donated by Frank Kirchhoff, University of Saarland) and floxed (flx) Kir6.1 mice (kindly donated by Andrew Tinker, QMUL) to allow deletion of Kir6.1 in NG2-expressing pericytes after oral gavage of tamoxifen