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In BAT, both lean and obese mice showed increased 3-AR expression following treatment, again paralleling reductions in BAT weight

Untargeted analysis of intracellular metabolites by UHPLC coupled to a Q-Exactive mass spectrometer (reversed-phase acetonitrile method) The profiling experiment was performed with a Dionex Ultimate 3000 UHPLC system (Thermo Scientific) coupled to a Q-Exactive (Thermo Scientific) equipped with an electrospray source operating in both positive and negative mode and full scan mode from 100 to 1,200 m/z

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Research in animal models has shown sustained reductions in body weight gain and increased fat oxidation over extended treatment periods, with individual results varying considerably based on adherence to diet and exercise protocols alongside peptide use

Guglielmotto, M

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