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Hyperammonemic encephalopathy, sometimes fatal, has been reported following initiation of valproate therapy in patients with urea cycle disorders, a group of uncommon genetic abnormalities, particularly ornithine transcarbamylase deficiency

Supplementary Table 1), and in people of European ancestry 11 (BMI % = 12.1% in Europeans versus 10.6% in non-Europeans

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The pigment accumulation is documented to be reversible if intake of the offending agent is avoided